Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation

作者：Lushuang Mao, Zhaofu Liao, Dong Tang, Yumin Qiu, Min Yang, Yanshang Li, Yituan Xie, Weimin Feng, Ze-jun Zheng, Xiaomeng Liu, Jiandong Ye, Shan-Shan Lu, Xin-bin Tang, Ming Shi, Yichen Qu, Heng Li, Zhixian Wu, Shun Xu, Xinguang Liu, Junjun Ding, Jian‐Jun Xie, Jun Tao, Xing‐dong Xiong · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.119709 · 被引用次数：4 · 研究领域：Single-cell and spatial transcriptomics、Genomics and Chromatin Dynamics、Angiogenesis and VEGF in Cancer

FOXP1 undergoes phase separation at its super-enhancer, recruiting transcription coactivators to form condensates. These condensates, in turn, facilitate binding with the SESN3 promoter and inhibit the mTORC1 signaling pathway, thereby delaying endothelial cell senescence.