Gellan gum-based composites hydrogel membranes with geranium and lemongrass oils for enhanced antibacterial and wound healing effect

作者：Ayesha Saleem, Ikram Ullah Khan, Yousaf Kamal, Yasir Mehmood, Zunera Chauhdary, Muhammad Irfan, Syed Haroon Khalid, Hafeez Ullah Khan, Usra, Ghulam Hussain, Amir Bouallegue, Atrsaw Asrat Mengistie, Rashed N. Herqash, Esmael M. Alyami, Abdullah R. Alanzi · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-25401-w · 被引用次数：2 · 研究领域：Wound Healing and Treatments、Hydrogels: synthesis, properties, applications、Advancements in Transdermal Drug Delivery

Currently, medical science is facing several issues such as microbial growth, prevalence of infections at wound site and resistance of common pathogens of wounds such as Staphylococcus aureus and Escherichia coli against synthetic molecules. Essential oils (EOs) are considered as promising alternative to synthetic molecules owing to antibacterial, antifungal, and antiinflammatory properties. Gellan gum based composite hydrogel membranes containing essential oils of geranium and lemongrass were prepared by solution-casting inotropic gelation method for effective wound healing. Hydrogel membranes were tested for their physicochemical properties, swelling index, in vitro antioxidant, and antibacterial potential. Solid-state characterization of prepared membranes elucidated the successful encapsulation of essential oils within the hydrogel matrix without any noticeable interaction. Scanning electron microscopy revealed smooth, uniform surface of blank ((gellan gum (G2) and gellan gum/collagen (GC7)) membrane while oil encapsulated formulations (Gellan gum/geranium oil (GG4), gellan gum/lemongrass oil (GL1), gellan gum/collagen/geranium oil (GCG4), and gellan gum/collagen/lemongrass oil (GCL1)) showed heterogeneous morphology. The antioxidant activity measured by DPPH free radical scavenging indicate that the GG4, GCL1 possessed strong % inhibition due to the presence of flavonoids and phenolic components. The GG4, GCL1 formulations revealed higher antibacterial activity against S...