Relationship between prior pregnancy loss and subsequent adverse pregnancy outcomes in women

作者：Ling Liu, Jian Zhang, Ruifang Wang, Wei Zhang, Kexin Wang, Fang Wang · 发表于：BMC Pregnancy and Childbirth · 年份：2025 · DOI：10.1186/s12884-025-08226-3 · 被引用次数：3 · 研究领域：Reproductive System and Pregnancy、Grief, Bereavement, and Mental Health、Reproductive Health and Contraception

Pregnancy loss is a prevalent issue among women of childbearing age and can have significant physical and psychological consequences for patients and their families. However, the association between the number of previous pregnancy loss and the risk of adverse pregnancy outcomes (APOs) in subsequent pregnancies remains uncertain. This study aimed to provide clinical data to determine whether the number of previous pregnancy loss increases the risk of APOs in women with a history of pregnancy loss. We conducted a cohort-based, nested case-control study involving 1074 women with a history of pregnancy loss. Detailed demographic and medical history information was collected at baseline, and biological specimens were retained for laboratory testing. APOs were selected as the primary outcome, with cases defined as individuals who experienced any APO events. Cases were matched with event-free control subjects at a 1:2 ratio. Using conditional logistic regression, we examined the relationship between the number of previous pregnancy loss and APO events, using age at first pregnancy as the reference exposure. Among the study participants, we identified 358 cases with APO events and 716 controls. The occurrence of APOs was found to be associated with an increased number of previous pregnancy loss exposures compared to controls without APOs, with an odds ratio (OR) of 1.36 and a 95% confidence interval (CI) of 1.14 to 1.61. This association persisted even after adjusting for patient de...