Postdomestication selection of MKK3 shaped seed dormancy and end-use traits in barley

作者：Morten Egevang Jørgensen, Dominique Vequaud, Yucheng Wang, Christian B. Andersen, Micha Bayer, Amanda Box, Katarzyna Braune, Yuanyang Cai, Fahu Chen, J.A. Cuesta-Seijo, Haoran Dong, Geoffrey B. Fincher, Zoran Gojković, Zihao Huang, Benjamin Jaegle, Sandip M. Kale, Flavia Krsticevic, Pierre-Marie Le Roux, Antoine Lozier, Qiongxian Lu, Martin Mascher, Emiko Murozuka, Shingo Nakamura, Martin Toft Simmelsgaard Nielsen, Pai Pedas, Pierre A. Pin, Dagmara Podzimska‐Sroka, Kazuhiro Sato, M. Spannagl, Magnus Wohlfahrt Rasmussen, Joanne Russell, Miriam Schreiber, Hanne Cecilie Thomsen, Nina W. Thomsen, Sophia Tulloch, Cynthia Voss, Birgitte Skadhauge, Nils Stein, Eske Willerslev, Robbie Waugh, Christoph Dockter · 发表于：Science · 年份：2025 · DOI：10.1126/science.adx2022 · 被引用次数：10 · 研究领域：Seed Germination and Physiology、Wheat and Barley Genetics and Pathology、Plant nutrient uptake and metabolism

Anthropogenic selection of grain traits such as dormancy has shaped the developmental trajectories of crops. In cereals, shortening dormancy provides rapid and even postharvest germination, but increases the risk of weather-induced preharvest sprouting, with yearly harvest losses beyond 1 billion dollars. Our understanding of how, why, when, and where cereal dormancy diversification arose is fragmentary. Here, we show in the founder crop barley ( Hordeum vulgare ) that dormancy is primarily regulated through a mosaic of locus haplotypes comprising copy number variation and inherent kinase activity of Mitogen-activated protein kinase kinase 3 ( MKK3 ). We provide evidence supporting the historical selection of specific MKK3 haplotypes that shaped dormancy levels according to changing climatic pressures and outline a genetic framework for breeders to balance grain dormancy and preharvest sprouting avoidance.