A trajectory study of postoperative frailty and cognitive function in elderly spinal surgery patients: a cohort study in China

作者：Rui Li, Qian Deng, Cheng Peng, Hong Ji Song, Xiaotian Shan, Yao Wang, Chunyan Jin · 发表于：Frontiers in Aging Neuroscience · 年份：2025 · DOI：10.3389/fnagi.2025.1554901 · 被引用次数：1 · 研究领域：Frailty in Older Adults、Intensive Care Unit Cognitive Disorders、Enhanced Recovery After Surgery

Objective To explore the developmental trajectory of postoperative frailty and cognitive function in elderly spinal surgery patients and the predictive relationship between the two. Methods A total of 266 elderly individuals were selected as the study subjects, and their debilitation and cognitive functions were tracked and investigated at T1 (at the time of discharge from the hospital), T2 (at 3 months postoperatively), and T3 (at 6 months postoperatively), and the data were analyzed using cross-lagged model and latent variable growth model. Results The latent variable growth model showed a decreasing trend in frailty (S = −0.197, p = 0.013) and an increasing trend in postoperative cognitive function (S = 0.124, p = 0.002) from T1 to T3 in elderly spinal surgery patients; at the initial level, frailty was negatively correlated with cognitive function ( r = −0.452, p < 0.001), and initial levels of frailty negatively predicted the self development rate ( β = −0.516, p < 0.001), the initial level of frailty negatively predicted the development rate of postoperative cognitive function ( β = −0.321, p = 0.003), and the initial level of postoperative cognitive function positively predicted the development rate of frailty ( β = 0.192, p = 0.031). Conclusion Elderly spinal surgery patients showed a decreasing trend of postoperative frailty and an increasing trend of postoperative cognitive function, frailty and postoperative cognitive function at the initial level had...