Causal Influences of Micronutrients on Anxiety: Insights From an Observational and Mendelian Randomization Analysis

作者：Xinyu Fang, Qian Zhao, Peizi Liu, Ancha Baranova, Hongbao Cao, Xiangrong Zhang, Fuquan Zhang · 发表于：Food Science & Nutrition · 年份：2025 · DOI：10.1002/fsn3.71166 · 被引用次数：3 · 研究领域：Folate and B Vitamins Research、Vitamin K Research Studies、Magnesium in Health and Disease

ABSTRACT An increasing number of studies have begun to focus on the role of micronutrients (vitamins and minerals) in mental disorders, including anxiety. Previous observational and clinical studies have suggested a relationship between micronutrients and anxiety, yet the causal link between them remains unclear. We aimed to detect the potential causal relationships between genetically predicted supplementation with vitamins (including vitamins A, B, B6, B12, C, D, E, folate, and multivitamins), minerals (including calcium, iron, magnesium, selenium, and zinc), and anxiety through Mendelian randomization (MR) analysis, the Bayesian colocalization analysis, and real‐world observational data. Summary genome‐wide association study datasets covering various supplements from the UK Biobank ( N = 64,979 ~ 462,933) and anxiety ( N = 346,542) from the FinnGen project R10 were utilized in our MR analyses. Then, the Bayesian colocalization analysis was used to validate the MR findings. Finally, we analyzed the association between micronutrients and anxiety by mining the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database (2004Q1 ~ 2024Q2). IVW‐based MR study revealed the significant protective effects of vitamin C (OR: 0.38, p = 0.032), magnesium (OR: 0.15, p = 0.035), and selenium (OR: 0.03, p = 0.020) against anxiety disorders. However, the colocalization analysis did not provide any evidence of shared causal variants between supplementation wit...