Electrochemical N–H Phosphorodithiolation of Sulfoximines with P 4 S 10 and Alcohols

作者：Peng Qian, Jinxiu Liu, Tianran Sheng, Jiusi Yang, Lexuan Zhang, Wenxuan Zhan, Kai Du, Dongping Zheng, Tongtong Zhu, Yuting Ren, Tingting Lu · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c04010 · 被引用次数：9 · 研究领域：Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions

Coupling dithiophosphates with sulfoximines is a promising strategy for generating diverse bioactive products, but a mild and efficient method is highly desirable. Herein, an electrochemical method has been developed to achieve N–H phosphorodithiolation of sulfoximines, providing N -(diethylphosphorodithioate) sulfoximines with moderate to good yields in the absence of external chemical oxidants. Furthermore, this approach can be extended to the synthesis of (dialkylphosphorodithioate) sulfoximines by employing in situ generated dialkylphosphorodithioate from P 4 S 10 and alcohols in one pot.