Global, regional, and national burden and trends of mental disorders in women of childbearing age: a systematic analysis based on the global burden of disease study 2021

作者：Hongli Xu, Juanjuan Ren, Hongmei Liu, Qingqing Xu, Ruixue Yuan, Dongmei Zhuang, Shunying Yu · 发表于：Annals of Medicine · 年份：2025 · DOI：10.1080/07853890.2025.2576642 · 被引用次数：3 · 研究领域：Maternal Mental Health During Pregnancy and Postpartum、Mental Health Treatment and Access、Menstrual Health and Disorders

OBJECTIVES: This study aims to provide a comprehensive picture of mental disorder burden in women of childbearing age (WCBA), providing scientific evidence for implementing disease prevention and control strategies. METHODS: Based on the data from the Global Burden of Disease study 2021, the age-standardized prevalence rates (ASPR) and disability-adjusted life years (DALY) rates (ASDR) of mental disorders in WCBA, along with their temporal trends, age-period-cohort effects and projection of epidemiological trajectory over the next 10 years were comprehensively analyzed. RESULTS: In 2021, there were an estimated 343.22 million mental disorder cases in WCBA, with a global ASPR of 17573.61 per 100,000 population and ASDR of 2696.58 per 100,000 population worldwide. Anxiety disorders accounted for the highest prevalence proportion (37.49%), while depressive disorders were the leading DALYs contributors (39.91%) in mental disorders. From 1990 to 2021, the global mental disorder burden showed significant upward trends, with ASPR and ASDR rising at annual average percent changes (AAPC) of 0.35 and 0.38 respectively. The deterioration was more pronounced in anxiety disorders (AAPC 0.74 and 0.73), eating disorders (AAPC 0.42 and 0.41) and depressive disorders (AAPC 0.39 and 0.45). The APC analysis indicated that the disease burden gradually increased with age, and the relative risk peaked during the period of 2017-2021. The projections suggest that the global burden of mental disorder...