Effective and safe use of immune checkpoint inhibitors for non‐small cell lung cancer in people living with HIV

作者：Rebekka Mispelbaum, Tessa Hattenhauer, Christian Hoffmann, Clara Lehmann, Franz‐Georg Bauernfeind, Peter Brossart, Maximilian Christopeit, Winfried Alsdorf, Carsten Bokemeyer, Julian Philipp Layer, Julia Roider, Marcus Hentrich, Malte B. Monin · 发表于：HIV Medicine · 年份：2025 · DOI：10.1111/hiv.70136 · 被引用次数：3 · 研究领域：Viral-associated cancers and disorders、Lung Cancer Treatments and Mutations、Lung Cancer Diagnosis and Treatment

Abstract Objectives With the near normalization of life expectancy in people living with HIV through antiretroviral therapy, the management of age‐related comorbidities has become increasingly important. Non‐AIDS‐defining cancers now contribute significantly to both morbidity and mortality in this population, with non‐small cell lung cancer (NSCLC) being one of the leading causes of cancer‐related deaths among people living with HIV. Methods Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of NSCLC in the general population. However, people living with HIV have been largely excluded from pivotal clinical trials, resulting in limited evidence regarding safety and efficacy in this population. This review summarizes the main available literature on ICI therapy in people living with HIV with NSCLC. Results The presented data from retrospective analyses and cohort studies suggest that people living with HIV benefit from ICI therapy, with similar response rates and survival outcomes as people living without HIV. The risk of immune‐related adverse events in people living with HIV was reported to be comparable to people living without HIV. Importantly, no significant effects of ICI on HIV viral load or CD4 + T cell count were reported. Conclusions ICI therapy appears to be both safe and effective in people living with HIV with NSCLC. Optimal management of this patient population requires close interdisciplinary collaboration between oncologists and HIV care speci...