Pharmacogenomics to Improve Supportive Care Symptoms. A Prospective Observational Study Protocol

作者：Martyn Patel, John McDermott, William G Newman, Caroline Barry · 发表于：NIHR Open Research · 年份：2026 · DOI：10.3310/nihropenres.14182.2 · 被引用次数：1 · 研究领域：Pharmacogenetics and Drug Metabolism、Pain Management and Opioid Use、Blood disorders and treatments

Background: People living with life limiting conditions such as incurable cancer often have problems with pain, vomiting and other symptoms which impact quality of life. Supportive and Palliative Care aims to improve people's symptoms, particularly towards the very end of life. Many medications exist that can be used to help with these symptoms, but often they do not work, or they cause side effects for the people taking them. "Pharmacogenomics" is a way of predicting who is more likely to have a good response to drugs, and who is more likely to get side effects, based on variation in their genes. Methods: A prospective observational study, recruiting 50 patients aged over 18, with life limiting conditions. The study aims to understand how the introduction of multi-gene pharmacogenetic test for patients receiving palliative and supportive care might impact routine prescribing practice in an acute NHS hospital setting. It will report on the nature of prescribing patterns over a 90-day period post recruitment, looking for any variation between patients with and without the presence of actionable drug-gene interactions. It will help determine the future feasibility of incorporating pharmacogenomic testing in a palliative care population based on recruitment targets versus actual recruitment achieved. A drug-gene interaction ratio for this cohort will be reported, giving an indication of the scale of the use of medications relevant to pharmacogenomics used in palliative care, and...