Existence and relevance of fulminant severe community-acquired pneumonia

作者：Francesco Salton, Jesús Villar, Michele Mondoni, Sergio Harari, Andrea Salotti, Alfonso Ambrós, Francisco Alba, Carlos Ferrando, Tomás Muñoz, Juan A. Soler, Lina Pérez‐Méndez, Cristina Fernández, Domingo Antonio Sánchez Martínez, Stefano Gasparotto, Stefano Centanni, Umberto Zuccon, Giulia Barbati, Andrea Rocca, Barbara Ruaro, Marco Confalonieri, Paola Confalonieri · 发表于：Pneumonia · 年份：2025 · DOI：10.1186/s41479-025-00180-0 · 被引用次数：2 · 研究领域：Pneumonia and Respiratory Infections、Nosocomial Infections in ICU、Sepsis Diagnosis and Treatment

BACKGROUND: Severe community-acquired pneumonia (sCAP) is a major contributor to global hospital mortality, with some patients rapidly progressing to death within a few days due to acute respiratory distress syndrome (ARDS), septic shock, or multiorgan failure (MOFS). Despite the significant health burden, these cases remain poorly defined, often overlooked in clinical practice, and insufficiently addressed in existing guidelines. METHODS: In this multicenter retrospective study, we analyzed 1,517 hospitalized patients with sCAP for assessing the incidence of fulminant pneumonia -defined as sCAP leading to death within 7 days from hospital admission- and to identify factors associated with either an increased or reduced risk of unfavorable outcome. RESULTS: Our findings revealed a 5.9% incidence of fulminant pneumonia, with early death primarily due to ARDS (93%), sepsis (70%), and MOFS (73%). Older age, obesity, diabetes, cardiovascular disease, and elevated serum creatinine were associated with increased risk, while early corticosteroid administration was associated with a significant mortality reduction within seven days, both in the univariate and multivariate analyses (OR 0.22, CI 95% 0.12–0.38, p < 0.001). Baseline respiratory impairment and inflammatory markers were not associated with early mortality. CONCLUSION: These findings highlight the importance of recognizing sCAP as a time-dependent condition, requiring early identification and treatment of cases at risk for ...