Middle meningeal artery embolization for migraine headaches – a prospective self-control cohort trial

作者：Kaya Xu, Junshuan Cui, Francis Demiraj, Guangtang Chen, Qingqing Wang, Maxim Mokin, Zisheng Yan, Han Peng, Yuanxin Huang, Zhongyong Peng, Xin Xiang, Liangzhao Chu, Shan Wu, Shibin Song, Yan Zheng, Lu Wang, Jing Cai, Yong Shao, Yuanrong Yao, Hua Yang, Zeguang Ren · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000003714 · 研究领域：Migraine and Headache Studies、Neurosurgical Procedures and Complications、Neurological Complications and Syndromes

BACKGROUND: Migraines are a leading cause of long-term disability. A neurovascular cause of migraines localizing to the middle meningeal artery (MMA), a branch of the external carotid artery, is believed to be a potential underlying mechanism given its anatomical connection to the dura. MATERIALS AND METHODS: We conducted a self-control pilot study of 15 participants with migraine headaches. All patients were recruited in 2024 and were followed for 90 days post-MMA embolization (MMAE). The inclusion criteria used in the study included men and women with age of 18-80 years with migraine with or without aura, intractable migraine with a disease duration of more than 3 months and migraine attacks > 8 times/month in the past 90 days before enrollment: poor response to two or more medications, or intolerable side effects, or the presence of contraindications to medical therapy. MMAE was achieved with coils, and the side of MMAE chosen by the side of symptom predominance. Migraine severity and disability scoring scales were used pre-embolization and three months post-embolization. RESULTS: 329 individuals were screened, and 15 patients were enrolled in the study. There were significant improvements in multiple migraine severity and disability scores, including days of headache a month (Z = - 2.938, P = .003), NRS score (Z = - 3.436, P = 0.001), VAS score (t = 6.085, P<0.001), VRS score (Z = - 4.064, P<0.001), MSQ (t = 4.706, P<0.001), HIT6 (t = 4.730, P<0.001, and MIDAS disability ...