Traumatic Spinal Cord Injury and Subsequent Risk of Developing Chronic Cardiovascular, Neurologic, Psychiatric, and Endocrine Disorders

作者：Ahmad Mashlah, Sandro Marini, Hunter Mills, Taha Yahya, Farid Radmanesh, Joshua I. Chalif, Benjamin E. Zusman, Joshua D. Bernstock, Maryam H. Al Mansi, Rachel Grashow, Muhammad M. Abd‐El‐Barr, Hasan A. Zaidi, Yi Lü, Alí Salim, Akl C. Fahed, Geoffrey T. Manley, Cathra Halabi, Anthony M. DiGiorgio, Ross Zafonte, Saef Izzy · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.41157 · 被引用次数：6 · 研究领域：Spinal Cord Injury Research、Aortic Disease and Treatment Approaches、Traumatic Brain Injury Research

Importance: While acute complications of traumatic spinal cord injury (TSCI) are well characterized, long-term systemic sequelae remain poorly understood, particularly in previously healthy individuals. Objective: To evaluate the long-term risk of neurologic, psychiatric, cardiovascular, and endocrine comorbidities and associated mortality in patients with TSCI compared with matched uninjured controls. Design, Setting, and Participants: This retrospective cohort study analyzed longitudinal data from 2 large hospital-based registries (January 1996 to January 2024): Mass General Brigham (MGB) and the University of California (UC) Health System. Individuals with preexisting diagnoses of studied comorbidities were excluded. Uninjured controls were matched 3:1 by age, sex, and race. The data were analyzed in September to December 2024. Exposure: TSCI. Main Outcomes and Measures: Incidence of cardiovascular, endocrine, neurologic, and psychiatric conditions, as defined by International Classification of Diseases, Ninth Revision (ICD-9) or Tenth Revision (ICD-10). Associations between TSCI and comorbidities, and their association with all-cause mortality, were evaluated using multivariable Cox and logistic regression models. Results: A total of 1038 patients with TSCI in the MGB cohort (602 [58%] male; median [IQR] age, 44 [31-59] years) and 1711 in the UC cohort (1111 [65%] male; median [IQR] age, 45 [32-58] years) were matched with 3114 uninjured control participants in MGB (media...