AASLD IDSA Practice Guideline on treatment of chronic hepatitis B

作者：Marc G. Ghany, Calvin Q. Pan, Anna Suk-Fong Lok, Jordan J. Feld, Joseph K. Lim, Su H. Wang, A Y Kim, Amy S. Tang, Mindie H. Nguyen, Susanna Naggie, Mark S. Sulkowski, Norberto Rodriguez‐Baez, Jacki Chen, M. Hassan Murad, Khaled S. Mohammad, Norah A. Terrault · 发表于：Hepatology · 年份：2025 · DOI：10.1097/hep.0000000000001549 · 被引用次数：80 · 研究领域：Hepatitis B Virus Studies、Hepatitis Viruses Studies and Epidemiology、Hepatitis C virus research

BACKGROUND AND AIMS: Accumulating data related to prevention, surveillance and treatment of chronic hepatitis B (CHB) provided the impetus for this updated guideline, using the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach. METHODS: The guideline was developed in compliance with the National Academy of Medicine standards. The guideline panel developed structured questions following the Population, Intervention Comparison, Outcomes (PICO) framework. The panel addressed 6 PICO questions covering prevention (maternal to infant transmission and horizontal transmission), surveillance for liver cancer (among hepatitis B surface antigen positive (HBsAg) persons co-infected with hepatitis C virus, hepatitis D virus and/or human immunodeficiency viruses and after HBsAg loss) and treatment (HBsAg positive persons in immune-tolerant or indeterminate phases as well as withdrawal of antiviral therapy), providing evidence-based recommendations on these topics. Four systematic reviews of the literature were conducted, and two existing systematic reviews were utilized to support the recommendations in this practice guideline. CONCLUSIONS: This evidence-based guideline provides updated recommendations to optimize the care of persons with CHB.