Platelet-to-albumin ratio as an indicator for Crohn’s disease activity and severity: a multicentre cross-sectional study

作者：Duo Xu, Bin Liu, Ziheng Peng, Yong Li, Xiaowei Liu, Yani Yin, Yu Peng · 发表于：BMJ Open · 年份：2025 · DOI：10.1136/bmjopen-2025-102524 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Inflammatory Bowel Disease、Platelet Disorders and Treatments

OBJECTIVES: Disease activity assessment is important for Crohn's disease (CD) management, since it involves the initial and subsequent therapeutic schedule. The purpose of this study is to identify a portable and reliable indicator for assessing and predicting activity and severity of CD. DESIGN: A multicentre, cross-sectional, diagnosis-based study. Data were obtained retrospectively from clinical records. SETTING: Patient data for the development cohort and internal validation cohort were collected from the Department of Gastroenterology, Xiangya Hospital, Central South University between January 2017 and June 2021. Patient data for the external validation cohort were collected from the Department of Gastroenterology, Xiangtan Central Hospital between January 2022 and April 2024. PARTICIPANTS: Inpatients diagnosed with CD were potential participants, and those with CD who also had other autoimmune diseases, malignant tumours, pregnancy or lactation were excluded. We identified 224 patients in the development cohort, 96 patients in the internal validation cohort and 80 patients in the external validation cohort. OUTCOME MEASURE: test and multivariate logistic regression analysis were used to identify independent predictors. Receiver operating characteristics curve analysis was used to evaluate the performance of integrated indices in CD activity and severity staging, and Delong's test was used for comparison. RESULTS: In the development cohort, platelet-to-albumin ratio (PAR...