The Associations of General, Central, Visceral Obesity, and Body Fat Percentage with Cognitive Impairment in the Elderly: Meta-analysis and Mendelian Randomization Study

作者：Di Lu, Xiang Ji, Yu An, Huiyuan Liu, Gang Zheng, Yashu Liu, Honghao Yang, Yuhong Zhao, Lu Zhao, Yang Xia · 发表于：Advances in Nutrition · 年份：2025 · DOI：10.1016/j.advnut.2025.100550 · 被引用次数：6 · 研究领域：Dementia and Cognitive Impairment Research、Genetic Associations and Epidemiology、Bariatric Surgery and Outcomes

It is unclear whether various obesity phenotypes are differently associated with cognitive disorders. The aim of this study was to examine the associations of general obesity [measured by body mass index (BMI)], central obesity [measured by waist circumference (WC), waist-to-hip ratio (WHR)], or body fat percentage (BFP), and visceral obesity with cognitive disorders in older adults using meta-analysis and Mendelian randomization (MR) approaches. We identified observational studies published from the inception of 4 (PubMed, Embase, Medline, and Web of Science) databases until November 2024. A random-effects model was employed to construct the pooled odds ratio (OR) and 95% confidence interval (CI) for exploring the associations of general, central, and visceral obesity with cognitive impairment. The mean, median, or range age of participants is ≥60 y. Subsequently, a 2-sample MR analysis was performed using genetic variation data to investigate the potential causal relationships of general, central, and visceral obesity with cognitive impairment. A total of 70 studies comprising 2,810,410 participants were included. In meta-analysis, general obesity (measured by BMI) showed an inverse association with cognitive disorders. Compared with normal BMI, the pooled ORs (95% CIs) were 1.29 (1.21, 1.38) for underweight, 0.87 (0.84, 0.90) for overweight, and 0.88 (0.85, 0.91) for obesity. In contrast, no significant association was observed for central obesity (WC or WHR) or visceral o...