Tailored Co 1– x Zn x Fe 2 O 4 Spinel Bulk Heterojunction Composites for Acetone Detection toward Diabetes Diagnosis

作者：Shiquan Chen, Xiangjian Liao, OU Yu-xiang, Xingyu Liu, Xingyu Liu, Zhonghui Shen, Yonglin Chen, Yifei Wang, Zixuan Wu, Aiping Huang, Xianzhe Liu, Xianzhe Liu, Jianyi Luo · 发表于：ACS Sensors · 年份：2025 · DOI：10.1021/acssensors.5c02635 · 被引用次数：3 · 研究领域：Gas Sensing Nanomaterials and Sensors、Advanced Chemical Sensor Technologies、Advanced Sensor and Energy Harvesting Materials

Acetone has been identified as a volatile organic compound (VOC) biomarker, whose concentration in exhaled breath shows a strong correlation with diabetic status. Consequently, reliable detection of trace acetone gas is of paramount importance for diabetes diagnosis. However, acetone gas sensors still encounter specific technical challenges, such as an excessively high detection limit and insufficient sensitivity. To develop high-performance acetone sensing materials, constructing highly reactive composites has emerged as an effective approach to modulate the sensing properties of gas-sensitive materials. Herein, Co 1– x Zn x Fe 2 O 4 spinel bulk heterojunction (BHJ) composites with mixed spinel structure were efficiently synthesized via a simple one-step solvothermal process. The optimized Co 0.5 Zn 0.5 Fe 2 O 4 sensor exhibited superior acetone-sensing performance, featuring a high response (S = 4.36 to 1 ppm acetone) and a low detection limit (S = 2.24 to 0.2 ppm acetone) at 200 °C. Significantly, the sensor could distinguish between exhaled breath samples from healthy individuals and those from simulated diabetic patients, indicating that Co 1– x Zn x Fe 2 O 4 composites represent a promising tool for noninvasive diabetes diagnosis via breath analysis.