The association of inflammatory response with speckled global strain in recovered patients with myocarditis

作者：Haitham Abu Khadija, Gilad Saar, Mohammad Alnees, Omar Ayyad, Amir Haim, Sara Shimoni, Jacob George, Sorel Goland · 发表于：Annals of Medicine and Surgery · 年份：2025 · DOI：10.1097/ms9.0000000000004210 · 被引用次数：1 · 研究领域：Viral Infections and Immunology Research、Pericarditis and Cardiac Tamponade、Cardiac Fibrosis and Remodeling

Objectives: This study aimed to investigate the relationship between simple, routinely available inflammatory markers and residual impairment of left ventricular (LV) function assessed by 2D global longitudinal strain (GLS) in patients recovered from myocarditis. Materials and Methods: This prospective study included patients diagnosed with Myocarditis who were followed in our heart failure clinic. All participants underwent conventional echocardiography and 2D strain analysis at follow-up. Echocardiographic data was compared with age and sex-matched healthy controls. The study group’s bloodwork was analyzed for inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), at defined time intervals starting from admission. Results: A total of 104 myocarditis patients [22 women, mean age 30.9 ± 8.5 years, baseline LV ejection fraction (LVEF) 56.8 ± 6.8%] were included. At a median follow-up of 78.4 months (IQR: 53.5–99.2), median GLS remained significantly less negative compared with healthy controls [–18.0% (IQR: −18.8 to −17.5) vs −21.4% (IQR: −22.7 to −19.4); P < 0.001]. At presentation, patients showed elevated inflammatory markers (WBC 10.7 ± 3.4 K/µL, NLR 5.53 ± 3.54, C-reactive protein 81.1 ± 67.7 mg/L), with WBC and NLR demonstrating an initial increase followed by significant decline at 72 hours and 6 months ( P < 0.001). Regression analyses confirmed impaired GLS in myocarditis patients compared to controls (crude β = 2.88, 95% CI: 2.21–3.55; adjuste...