Targeting the Gut–Mammary Axis for Understanding Mastitis Pathogenesis and Therapeutic Strategies

作者：Yan Li, Menghan Wang, Wenqiang Liu, Mingyang Geng, Mohammed Asiri, Fuad M. Alzahrani, Khalid J. Alzahrani, Qingshan Ma, Changfa Wang, Muhammad Zahoor Khan · 发表于：Veterinary Sciences · 年份：2025 · DOI：10.3390/vetsci12111049 · 被引用次数：5 · 研究领域：Milk Quality and Mastitis in Dairy Cows、Gut microbiota and health、Probiotics and Fermented Foods

Mastitis represents one of the most economically devastating diseases in dairy production, causing billions of dollars in annual losses through reduced milk quality and quantity. Recent advances in microbiome research have unveiled a critical gut–mammary axis that fundamentally influences mastitis susceptibility and pathogenesis in dairy cattle. Through comprehensive analysis of microbial communities across multiple anatomical sites, we demonstrate that mastitis development involves systematic disruption of both mammary and gastrointestinal microbiomes, characterized by reduced beneficial bacterial populations and increased pathogenic species. Healthy animals maintain balanced microbial ecosystems dominated by protective taxa including Firmicutes, Bacteroidetes, and beneficial Lactobacillus species, while mastitis-affected animals exhibit dysbiotic shifts toward Proteobacteria dominance, elevated Streptococcus and Staphylococcus populations, and compromised microbial diversity. Mechanistic investigations reveal that gut microbiota disruption compromises systemic immune competence, alters metabolite production including short-chain fatty acids and bile acids, and influences inflammatory mediators that circulate to mammary tissue. Therapeutic interventions targeting this axis, including probiotics, prebiotics, and plant-derived compounds, demonstrate significant efficacy in restoring microbiome homeostasis and reducing mastitis severity. These findings establish the gut–mammary...