Efficacy of external physical vibration lithecbole combined with tamsulosin in upper ureteric stones after ESWL: a prospective randomized clinical trial

作者：Hexiang Xu, Xiao Liang, Yuhao Wang, Yuanji Xu, Huiqing Li, Yunpeng Li · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-22157-1 · 被引用次数：1 · 研究领域：Kidney Stones and Urolithiasis Treatments、Endodontics and Root Canal Treatments、Ureteral procedures and complications

This study aimed to evaluate the efficacy and safety of combining external physical vibration lithecbole (EPVL) with tamsulosin to enhance the clearance of upper ureteric stones (10-20 mm) after extracorporeal shock wave lithotripsy (ESWL). In a prospective, randomized clinical trial, patients with upper ureteric stones were allocated to a control group receiving ESWL followed by daily tamsulosin (0.4 mg) or a treatment group receiving both ESWL and EPVL in addition to tamsulosin. The primary endpoint, the stone-free rate (SFR), was assessed at 1, 2, and 4 weeks post-ESWL. Secondary endpoints included complication rates, with radiologic evaluations conducted at predetermined intervals to monitor stone clearance. In this randomized trial involving 211 participants, 106 received the intervention, while 105 served as controls. EPVL significantly enhanced stone fragment clearance. At week one, the SFR between the groups was similar (51.9% vs. 45.4%, P = 0.912). However, at weeks two and four, the treatment group demonstrated significantly higher SFR of 81.1% and 90.6%, respectively, compared to 64.8% and 75.2% in the control group (P = 0.020 and P = 0.011). No significant differences were observed in complication rates (P > 0.05). The treatment group underwent an average of 6.2 EPVL sessions, with a mean stone expulsion time of 20.3 ± 4.7 days. The combination of EPVL and tamsulosin following ESWL significantly increased the SFR while maintaining a favorable safety profile, sugge...