Clinicopathological features and prognosis of patients with colorectal Mucinous adenocarcinoma mixed with other pathological components: a nationwide retrospective study in China

作者：Jianlin Yuan, Hao He, Ping Zhang, Xu Guan, Ming‐Whei Yu, Ying Zhang, Shipeng Ning, Yaohui Wang, Ying Lv, Min Jiao, Yueming Sun, Qi Sun, Xianghai Ren, Dong Liu, Zhaoyang Zhang, Zhaochen Ye, Jie Li, Guodong Yu, Bin Ma, Weiling Fu, Xiaohong Kong, Changqing Jing, Kaixiong Tao, Yueming Sun, Congqing Jiang, Jun Chen, Guangyong Zhang, Haijun Yang · 发表于：Techniques in Coloproctology · 年份：2025 · DOI：10.1007/s10151-025-03225-0 · 被引用次数：3 · 研究领域：Colorectal Cancer Screening and Detection、Colorectal Cancer Surgical Treatments、Pancreatic and Hepatic Oncology Research

BACKGROUND: Mucinous adenocarcinoma (MAC) is typically admixed with other pathological components, including conventional adenocarcinoma, signet ring cell carcinoma, and/or neuroendocrine neoplasms. Specifically, signet ring cell differentiation (MASD) is defined as a signet ring cell component comprising less than 50% of the tumor, and neuroendocrine differentiation (MAND) is defined as a neuroendocrine component constituting less than 30%. Furthermore, MAC admixed with conventional adenocarcinoma was defined as classic mucinous adenocarcinoma (CMAC) in this study. Therefore, the study aimed to investigate the clinicopathologic and prognostic differences between patients with CMAC and those with either MASD or MAND [collectively termed mucous adenocarcinoma mixed with other pathological components (MAM)]. METHODS: We collected data from a multi-institutional registry of patients who underwent surgical curative resection for histologically proven MAC between January 2016 and September 2021 at 22 medical institutions in China. Patients with MAC with percentage of signet ring cell ≥ 50% or percentage of neuroendocrine component ≥ 30% were excluded. RESULTS: A total of 2023 patients from 22 medical institutions who met the study criteria were included. MAM, compared to CMAC, showed more aggressive histologic features, including higher rates of lymphovascular invasion (47.0% vs. 18.0%, p < 0.01), perineural invasion (68.0% vs. 35.1%, p < 0.01), T4 stage (33.5% vs. 26.5%, p < 0.01...