Effectiveness of 0.01% atropine and orthokeratology for incipient myopia: a 1-year retrospective study

作者：Xiaona Sun, Huihui Chu, Ru Zhang, Lingling Han, Jifeng Yu · 发表于：BMC Ophthalmology · 年份：2025 · DOI：10.1186/s12886-025-04448-3 · 被引用次数：1 · 研究领域：Ophthalmology and Visual Impairment Studies、Corneal surgery and disorders、Visual perception and processing mechanisms

PURPOSE: To investigate and compare the effectiveness of 0.01% low-dose atropine (LA) and orthokeratology lenses (OK) monotherapy versus single-vision spectacles (SV) in controlling low myopia in clinical settings. METHODS: Treatment-naïve Children with a first diagnosis of myopia using single vision spectacles (SV), LA, or OK for at least 1 year were included in this retrospective study. Data from 140 children’s eyes were analyzed at baseline (before the initiation of treatment) and after 1 year of treatment. ANOVA, ANCOVA, and Multiple Liner Regression were undertaken to identify factors significantly associated with axial length (AL) elongation and spherical equivalent refraction (SER) progression over this period. RESULTS: After controlling baseline variates, the adjusted 1-year AL growth of the LA group (0.22 ± 0.54 mm, adjusted p < 0.00) and the OK group (0.30 ± 0.23 mm, adjusted p < 0.00) was slower than that of SV group (0.57 ± 0.41 mm), and there was no statistically significant difference in AL growth between the LA group and the OK group (adjusted p = 0.29). The 1-year SER progression of each treatment group differed significantly (p < 0.00). Specifically, the slowest progression of SER occurred in the group receiving the LA intervention (-0.16 ± 0.38D) compared to the SV group (-0.56 ± 0.42D), followed by the OK group (-0.34 ± 0.34D). Baseline AL (β=-0.299, p < 0.00) and baseline SER (β=-0.255, p < 0.00) were negatively correlated with AL elongation and SER change...