High Willingness to Use and Recommend Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention in Peru

作者：Jorge A. Gallardo-Cartagena, Dora Leidy Geraldine German-Quiñones, Fanny G. Rosas-Benancio, Karla T. Tafur, David R. Velásquez-Velásquez, Robinson Cabello, Kelika A. Konda, Connie Celum, Jorge Sánchez · 发表于：Sexually Transmitted Diseases · 年份：2025 · DOI：10.1097/olq.0000000000002268 · 被引用次数：2 · 研究领域：Reproductive tract infections research、HIV/AIDS Research and Interventions、Infection Control in Healthcare

BACKGROUND: Bacterial sexually transmitted infections (STIs) remain prevalent among men who have sex with men (MSM) and transgender women (TGW) in Peru. Doxycycline postexposure prophylaxis (doxy-PEP) is a promising prevention strategy, but data from Latin America remain limited. METHODS: We conducted 2 online surveys in Lima, Peru (September-October 2024). One assessed willingness to use doxy-PEP among MSM and TGW; the other assessed willingness to recommend doxy-PEP among health care providers (HCPs). Logistic regression evaluated correlates of high willingness. RESULTS: Of 730 eligible MSM and TGW, 447 completed outcome measures. Overall, 82.1% expressed willingness to use doxy-PEP, 34.2% expressed high willingness. High willingness was associated with ≥5 anal sex partners in the past 3 months (adjusted odds ratio [aOR], 1.86; 95% confidence interval [CI], 1.06-3.24), prior HIV preexposure prophylaxis use (aOR, 2.56; 95% CI, 1.40-4.71), living with HIV (aOR, 2.74; 95% CI, 1.44-5.24), and concern about needing a prescription (aOR, 3.33; 95% CI, 1.99-5.66). Concerns about side effects (aOR, 0.55; 95% CI, 0.31-0.98) and microbiome disruption (aOR, 0.51; 95% CI, 0.29-0.87) were negatively associated. Most participants preferred doxy-PEP over daily doxycycline (64.0% vs. 28.6%). Among 132 HCPs, 54.5% were involved in HIV/STI care; 87.1% expressed willingness to recommend doxy-PEP, and 89.4% would do so if included in national guidelines. Limited diagnostic capacity and risk of ...