Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity

作者：Yifan Jing, Meng Zhang, Yuan Liu, Ying Gao, Bin Zhang, Chengfeng Chen, Zaimina Xuekelaiti, Yan Zhou, Changlin Zhang, Meijuan Li, Jie Li · 发表于：BMC Psychiatry · 年份：2025 · DOI：10.1186/s12888-025-07483-y · 被引用次数：2 · 研究领域：Suicide and Self-Harm Studies、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Tryptophan and brain disorders

BACKGROUND: Suicide thoughts and behaviors (STB), including suicidal ideation (SI) and suicide attempts (SA), are significant concerns in major depressive disorder (MDD), yet their neurobiological mechanisms remain poorly understood. This study aims to identify key regional brain activity and connectivity abnormalities associated with STB in MDD by combining a meta-analysis of regional brain activity comparing MDD patients with STB to non-STB controls (both MDD without STB and healthy controls) and an exploratory functional connectivity (FC) analysis in an independent sample of MDD patients. METHODS: A meta-analysis employing Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software identified regional brain abnormalities. Studies included were those comparing MDD patients with STB to non-STB controls, employing resting-state fMRI with whole-brain analyses, using ALFF, fALFF, and ReHo metrics. The identified abnormal brain regions were used as regions of interest (ROIs) for FC analyses in 57 first-episode, drug-naive MDD patients. RESULTS: The meta-analysis included 12 studies (13 datasets) comprising 555 MDD patients with STB and 430 non-STB controls. Compared to non-STB controls, MDD-STB patients showed increased activity in the right middle occipital gyrus (MOG) and right inferior frontal gyrus, triangular part (IFGtriang), while decreased activity in right precuneus. Subgroup analysis of SA revealed increased activity in the left angular gyrus in MDD pati...