Deep learning radiomics and 18F-FDG PET/CT imaging: mediastinal lymph node characteristics as predictors of metastasis in non-small cell lung cancer

作者：Furui Duan, Hanyu Zu, Rui Zhang, Li Yan, Yu Zhao, Xuewei Wang, Minghui Zhang, Ping Li, Dalong Wang · 发表于：Translational Lung Cancer Research · 年份：2025 · DOI：10.21037/tlcr-2025-650 · 被引用次数：6 · 研究领域：Radiomics and Machine Learning in Medical Imaging、Lung Cancer Diagnosis and Treatment、Advanced X-ray and CT Imaging

Background: In non-small cell lung cancer (NSCLC), accurate lymph node staging is vital for prognosis and treatment planning. However, positron emission tomography/computed tomography (PET/CT) is limited by false positives, and morphology-based criteria lack reliability. This study aimed to develop and validate a PET/CT-based deep learning radiomics (DLR) approach to distinguish benign from malignant lymph nodes. Methods: A total of 217 hypermetabolic lymph nodes from 185 NSCLC patients were retrospectively analyzed. Radiomics and DenseNet121-based deep network features were extracted from PET/CT images. Clinical and imaging variables were selected using logistic regression (LR), correlation analysis, and recursive feature elimination (RFE). Nine machine learning models were trained and externally validated; diagnostic performance was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC), accuracy, sensitivity, specificity, and F1 score. Results: Our study demonstrated that the artificial neural network (ANN) and extra trees (ET) models exhibited superior diagnostic performance in identifying suspected malignant lymph nodes in NSCLC patients. Specifically, the ANN achieved an AUC of 0.865, sensitivity of 66.7%, and accuracy of 82.0% on the test set, while the ET model performed best in the external validation set with an AUC of 0.865, sensitivity of 76.9%, and accuracy of 80.4%. Tumor location, lymph node long-to-short axis (L/S) ratio, and bilat...