Biomimetic Manganese Mineralized Chemoimmunological Microneedles Priming cGAS‐STING for Robust Cascade Cancer Therapy

作者：Jingjing Zhang, Fan Xie, Yunyang Zhang, Siying Chen, Wenjun Shi, Xinyan Yang, Yunjiu Ren, Yao Li, Mayakrishnan Arumugam, Xiangdong Kong, Ruibo Zhao · 发表于：Small · 年份：2025 · DOI：10.1002/smll.202506115 · 被引用次数：2 · 研究领域：Nanoplatforms for cancer theranostics、Advancements in Transdermal Drug Delivery、Graphene and Nanomaterials Applications

Dissolvable microneedle-based transdermal superficial technique demonstrates promised integrative potential for triple-negative breast cancer (TNBC) therapy, yet their insufficient mechanical strength restricts to puncture, attributed to the high-density tumor stroma and elasticity of TNBC, limiting long-distance therapeutics penetration and profound treatment in situ, posing a significant barrier to achieving effective therapy for TNBC management. Inspired by biomineralization, herein, a novel strategy is presented for a robust microneedle involving manganese phosphate biomimetic mineralization, which is characterized by a homogeneous inorganic-organic intercross modification, achieving high mechanical strength and solubility. Furthermore, the chemotherapy drug, doxorubicin (DOX), can be facilely integrated into this biomimetic process, facilitating chemoimmunological microneedles (MD-MN). Subsequently, the MD-MN provides high robustness for tumor injection followed by releasing manganese and DOX within the tumor, and the manganese can reduce tumor stroma and enhance deep DOX infiltration, exerting significant cancer cell apoptosis. Furthermore, manganese elements can reverse the immunosuppressive microenvironment by activating cGAS-STING, which taken together, constructs a boosted cascade chemoimmunological therapy for TNBC. These achievements present a successful integrative strategy for circulated cascade chemoimmunological treatment for TNBC, indicating a great potential...