Pro-dopaminergic pharmacological interventions for anhedonia in depression: a living systematic review and network meta-analysis of human and animal studies

作者：Edoardo G. Ostinelli, Georgia Salanti, Malcolm Macleod, Virginia Chiocchia, Katharine Smith, Argyris Stringaris, James Downs, Emma Robinson, Gin S. Malhi, Dominic M. Dwyer, Astrid Chevance, Christoph U. Correll, Thomy Tonia, Emily C. Wheeler, Toshi A. Furukawa, Diego A. Pizzagalli, Michael Browning, Jennifer Potts, Andrea Cipriani · 发表于：EBioMedicine · 年份：2025 · DOI：10.1016/j.ebiom.2025.105967 · 被引用次数：4 · 研究领域：Treatment of Major Depression、Neurotransmitter Receptor Influence on Behavior、Mental Health Research Topics

BACKGROUND: It is unclear whether pro-dopaminergic drugs reduce anhedonia in major depressive disorder (MDD) and further, if so, to what extent this is the case. METHODS: With lived experienced experts we co-produced two living systematic reviews of randomised controlled trials (RCTs) investigating the relative efficacy of pro-dopaminergic interventions in reducing symptoms of anhedonia in people with MDD (versus placebo) and in relevant non-human animal models (versus vehicle control/no intervention). Multiple electronic databases were searched until June 9, 2024. The primary outcomes were subjective anhedonia symptoms in humans and sucrose preference test (a measure of reward sensitivity and proxy for anhedonia) in animals. We evaluated other important domains and clinical aspects closely related to anhedonia, such as reward/reinforcement tasks, anxiety symptoms, acceptability, tolerability, and adverse events. We performed pairwise meta-analyses separately for human and non-human studies. We also estimated the relative effects of pro-dopaminergic versus non-dopaminergic antidepressants in human studies on anhedonia and overall depressive symptoms using a series of random-effects network meta-analyses of both aggregate and patient-level data. A multidisciplinary panel of international experts (including people with lived experience) then interpreted the overall results and produced a list of recommendations via a triangulation process. This study is part of GALENOS (Global ...