High‐Fidelity T2 Relaxometry of the Developing Fetal Brain Using an 8‐Second Single‐Shot Multiple Overlapping‐Echo Detachment ( MOLED ) MRI Technique

作者：Nien‐Hui Ge, Qinqin Yang, Chenyu Yan, Fei Wu, Yong Zhang, Dan Wu, Zhong Chen, Jianhui Zhong, Congbo Cai, Jianfeng Bao, Shuhui Cai · 发表于：Journal of Magnetic Resonance Imaging · 年份：2025 · DOI：10.1002/jmri.70164 · 被引用次数：2 · 研究领域：Fetal and Pediatric Neurological Disorders、Neonatal and fetal brain pathology、Advanced Neuroimaging Techniques and Applications

BACKGROUND: Although quantitative MRI can provide objective biomarkers for brain maturation assessment, unpredictable fetal movement limits its application on fetuses. PURPOSE: To evaluate single-shot multiple overlapping-echo detachment (MOLED) imaging for fetal brain T2 relaxometry and to quantify fetal brain maturation using T2 relaxation time. STUDY TYPE: Phantom and prospective in vivo assessment. SUBJECTS: T2 phantom and 52 fetuses (mean gestational age [GA], 30.94 ± 3.62 weeks; range, 23-37 weeks). FIELD STRENGTH/SEQUENCE: 3T; half-Fourier acquisition single-shot turbo spin-echo (HASTE) and MOLED sequences. ASSESSMENT: The accuracy, motion robustness, and repeatability of 8-s MOLED T2 relaxometry were assessed using motion-free and motion phantom acquisitions. In 15 fetuses, the MOLED scan was repeated within 5 min to assess scan-rescan repeatability. Regional T2 values were determined in fetal white matter (WM), deep gray matter (dGM) and brainstem, and their changes with GA evaluated. STATISTICAL TESTS: Bland-Altman analysis, linear regression analysis (Pearson correlation coefficient, r), coefficient of variation, repeated-measures analysis of variance, and intraclass correlation coefficient. p < 0.05 was considered statistically significant. RESULTS: Motion-free and motion phantom acquisitions demonstrated that MOLED T2 significantly agreed with reference T2 (r = 0.99). In vivo studies reported mean T2 values for all fetuses (WM, 215.20 ms; dGM, 145.82 ms; brainste...