Fatty Acid Oxidation Metabolites in Aquatic Animals: Metabolic Pathway, Dynamic Remodeling, and Functional Implications

作者：Zengqi Zhao, Baolin Li, Shunlang Wen, Jianlong Du, Xiuwen Li, Bingyuan Yang, Kangsen Mai, Qinghui Ai · 发表于：Reviews in Aquaculture · 年份：2025 · DOI：10.1111/raq.70099 · 被引用次数：5 · 研究领域：Aquaculture disease management and microbiota、Aquaculture Nutrition and Growth、Peroxisome Proliferator-Activated Receptors

ABSTRACT As fundamental components of metabolic networks, metabolites act as both energy carriers and signaling molecules, orchestrating a wide range of physiological functions. Consequently, the abundance of metabolites within tissues and cells is typically under tight regulation, with any perturbation of this metabolic equilibrium frequently triggering diverse stress responses and diseases. Recent studies demonstrated that nutritional, environmental, and pathogenic stimuli factors during aquaculture may lead to the remodeling of the fatty acid oxidation pathway in aquatic animals, altering the abundance of fatty acid oxidation‐related metabolites and subsequently triggering stress response cascades. Thus, elucidating the functional roles and regulatory mechanisms of these metabolites is critical for developing targeted strategies to mitigate these stress responses. However, the current progress of research on metabolites related to fatty acid oxidation in aquatic animals is not well summarized. Therefore, in this study, we characterize the fundamental pathways of fatty acid oxidation in aquatic animals and summarize the mechanisms by which these metabolic pathways respond to diverse aquaculture‐related stressors. Furthermore, we systematically elucidate the mechanisms through which these metabolites mediate their regulatory functions, highlighting the distinct physiological roles of the key metabolites. Additionally, we provide our perspectives on the potential applications...