Measuring Phase–Amplitude Coupling Effect with OPM-MEG

作者：Yong Li, Hao Lu, Chunhui Wang, Fuzhi Cao, Jianzhi Yang, Binyi Su, Ying Liu, Xiaolin Ning · 发表于：Photonics · 年份：2025 · DOI：10.3390/photonics12111070 · 被引用次数：1 · 研究领域：Atomic and Subatomic Physics Research、Functional Brain Connectivity Studies、Neural dynamics and brain function

Optically pumped magnetometers (OPMs) present a promising opportunity to advance magnetoencephalography (MEG), enhancing the accuracy of neuronal activity recordings due to their high spatiotemporal resolution. However, to fully realize the potential of OPM-MEG as an emerging brain functional imaging technology, it is essential to measure key indicators of neural dynamics, particularly phase–amplitude coupling (PAC). PAC is a fundamental mechanism for integrating information across different frequency bands and plays an important role in various cognitive functions and neurological disorders. Therefore, measuring PAC with OPM-MEG is a crucial step toward expanding its applications. In this study, brain signals under pitch sequence stimulation were recorded using OPM-MEG to analyze the PAC effect in the primary auditory cortex (Aud) and the inferior frontal gyrus (IFG), as well as the functional connectivity between brain regions. The findings were validated through EEG control experiments. The results indicated that the PAC effect measured by OPM-MEG was largely consistent with that measured by EEG, with OPM-MEG appearing to detect PAC more prominently under the current experimental conditions. The PAC of Aud exhibited a trend of initially increasing and then decreasing centered on the target pitch, showing hemispheric symmetry. The PAC of IFG showed variations under different pitch conditions and displayed right hemisphere lateralization. Functional connectivity analysis pro...