Neurocognitive Functioning and Impulsivity in Veterans With Bipolar Spectrum Disorders

作者：Chi Chuen Chan, Sharon Alter, Isabelle Baptista, Terra Osterberg, R. Sweeney, Marianne Goodman, Erin A. Hazlett, M. Mehmet Haznedar, Philip R. Szeszko · 发表于：The Journal of Clinical Psychiatry · 年份：2025 · DOI：10.4088/jcp.25m15832 · 被引用次数：1 · 研究领域：Suicide and Self-Harm Studies、Bipolar Disorder and Treatment、Schizophrenia research and treatment

Veteran status and bipolar disorder (BD) are two substantial risk factors for suicide. Models of suicide implicate neurocognition and impulsivity in suicidal behavior. We aim to examine neurocognitive dysfunction and impulsivity correlates of suicide in veterans with BD. bipolar spectrum disorder with a suicide attempt history (BD/SA+), 33 veterans with bipolar spectrum disorder without a suicide attempt history (BD/SA-), and 22 healthy control veterans (HC) recruited between January 2021 and July 2023. Participants were administered the MATRICS Consensus Cognitive Battery; Barratt Impulsivity Scale; Urgency, Premeditation, Perseverance, Sensation Seeking, Positive Urgency Impulsive Behavior Scale; and Impulsive/Premeditated Aggression Scale. = .003) aggression. Results suggest that in veterans with BD, poorer working memory is associated with suicide attempt independent of depression, while verbal learning impairments associated with suicide attempt may be influenced by depression. Neurocognitive dysfunction may underlie aggression to drive suicidal behavior. Findings support the role of neurocognition in models of suicide in BD and can inform risk detection and intervention.