Analysis of factors affecting smooth extubation in delayed extubation patients following intracranial surgery: an ambispective cohort study

作者：Rui Wang, Yan Liu, Weina Li, Chao Zhang, Xia Zhang, Feilong Wang, Yuhong Li, Xueli Yang, Binbin Tan, Tunan Chen, Jishu Xian · 发表于：BMC Anesthesiology · 年份：2025 · DOI：10.1186/s12871-025-03394-3 · 被引用次数：3 · 研究领域：Intraoperative Neuromonitoring and Anesthetic Effects、Respiratory Support and Mechanisms、Anesthesia and Sedative Agents

OBJECTIVE: Delayed extubation is common after intracranial surgery, and is associated with adverse reactions that compromise patient safety and comfort. Identifying factors that influence smooth extubation is therefore critical, but available evidence is limited. This study aims to explore risk factors of extubation adverse outcomes in patients undergoing craniocerebral surgery, with the goal of enhancing extubation safety and patient comfort. METHODS: An ambispective cohort study was conducted at a university hospital from May 2022 to September 2023, involving 157 patients with delayed extubation post-intracranial surgery. Clinical data encompassing demographic characteristics, neurological status, respiratory parameters, intraoperative and anesthetic management, and postoperative factors. Smooth extubation was defined as extubation with stable blood pressure, respiratory function, and absence of pain or agitation. Multivariate logistic regression identified independent factors influencing adverse extubation. RESULTS: , airway patency, Duration from command obedience to extubation, time to extubate, types of surgical procedure, operation duration, intraoperative propofol use, sedation before. Multivariate analysis showed: age [OR = 2.791, 95%CI (1.268, 6.147)], intraoperative propofol use [OR = 0.298, 95%CI (0.012, 0.796)], preoperative airway patency [OR = 2.463, 95%CI (1.159, 5.234)], time to extubate [OR = 7.884, 95%CI (1.337, 46.472)] as independent factors of dverse ext...