Brillouin Metrics of the Crystalline Lens Comparison Between Low-Medium Myopia and High Myopia

作者：Yongle Bao, Yong Ma, Jian Cao, Yanze Yu, Teruko Fukuyama, Zhe Zhang, Lingling Niu, Peijun Yao, Xiaoying Wang, Xingtao Zhou, Jing Zhao · 发表于：Clinical ophthalmology · 年份：2025 · DOI：10.2147/opth.s555070 · 被引用次数：2 · 研究领域：Ophthalmology and Visual Impairment Studies、Advanced Fluorescence Microscopy Techniques、Digital Holography and Microscopy

Purpose: To investigate the impact of myopia on the Brillouin biomechanics and morphology of crystalline lenses in Chinese adults. Methods: Patients with myopia were enrolled and divided into low-medium (spherical equivalent [SE] ≥ − 5.75 D, N = 66) and high (SE ≤ – 6.0 D, N = 72) myopia groups. All patients underwent routine ophthalmic examinations, including SE, axial length, and anterior chamber metrics (Pentacam) measurements. The Brillouin-related metrics of the crystalline lenses were measured using a Brillouin microscopy. The morphological parameters included the Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Bottom-Top (B-T), Slope of Anterior Cortex (SAC), and Slope of Posterior Cortex (SPC). The height of Plateau was a biomechanical parameter. Results: The study included 138 eyes (138 patients); the mean age was 28.43 ± 8.31 years. WBP, B-T, SAC, and SPC significantly differed between the high and low-medium myopia groups (all P < 0.05). WBP, B-T, and SPC significantly correlated with SE in the high myopia group (Pearson’s r = 0.365, 0.287, and 0.294, respectively; all P < 0.05) but not in the low-medium group. The SPC significantly decreased for all participants based on the SE values ( P < 0.05). The biomechanics and thickness of the nucleus displayed no discrepancies with SE in all participants (all P > 0.05). Conclusion: An increase in the degree of myopia could be associated with posterior cortex thickening while maintaining stable biomechanics and ...