Single-cell and spatial transcriptomics reveal intratumor heterogeneity and immune evasion in natural killer/T cell lymphoma

作者：Shu‐Yun Ma, Biaojie Huang, Jiahui Wang, Ru Lv, Dan‐Ling Dai, Qian Zhong, Yi Xia, Panpan Liu, Youqiong Ye, Kui Wu, Shichen Dong, Jun Cai, Qihua Zou, Yuchen Zhang, Lirong Li, Guibo Li, Wenlong Zhong, Lei Wang, Qingqing Cai · 发表于：iScience · 年份：2025 · DOI：10.1016/j.isci.2025.113626 · 被引用次数：2 · 研究领域：Lymphoma Diagnosis and Treatment、Immune cells in cancer、Immune Cell Function and Interaction

. Furthermore, ligand-receptor interaction analysis reveals that tumor-associated macrophages (TAMs) may facilitate immune evasion and suppress T cell activity within the TME. Collectively, our findings elucidate the cellular heterogeneity and immune landscape of NKTCL, offering potential targets for therapeutic intervention.