Multilayered Regulation of Fungal Phosphate Metabolism: From Molecular Mechanisms to Ecological Roles in the Global Phosphorus Cycle

作者：Yanan Tan, Yanda Ning, Siyi Wang, Faqin Li, Xue‐Wei Cao, Qin Wang, Ang Ren · 发表于：Life · 年份：2025 · DOI：10.3390/life15111676 · 被引用次数：6 · 研究领域：Fungal and yeast genetics research、Mycorrhizal Fungi and Plant Interactions、Plant nutrient uptake and metabolism

Phosphates are essential nutrients for living organisms, and they are involved in various biological processes, including lipid metabolism, energy synthesis, and signal regulation. Recent studies have elucidated the fundamental components and transport proteins of phosphate signaling pathways, thereby providing a more profound understanding of phosphate metabolism in fungi. In this review, we concentrate on synthesizing the recent findings concerning phosphate metabolism in fungi over the past five years. These findings include the role of phosphates in the global phosphorus cycle, their effect on fungal growth and development, the variations in PHO signaling pathways among different species, and their pivotal role in symbiosis with plants. A mounting body of research substantiates the notion that phosphates play a pivotal role in regulating fungal life activities through a multifaceted mechanism. This regulatory function encompasses the promotion of growth and development, adaptation to environmental variations among different fungal species, and the evolution of distinct regulatory factors and transport proteins. Consequently, this fosters fungal diversity.