Suicidal ideation in patients with atopic dermatitis: A case‐control study on 23,191 adults

作者：Julien Sénéschal, Bruno Halioua, Jerry Tan, Chaoying Gu, Thomas A. Luger, Roni P. Dodiuk‐Gad, Roberto Takaoka, Flavia Pretti Aslanian, Cita Rosita Sigit Prakoeswa, Anne‐Laure Demessant‐Flavigny, Caroline Le Floc'h, Nabil Kerrouche, Stéphanie Mérhand, Wendy Smith Begolka, África Luca de Tena Smith, Shulamit Burstein, Delphine Kérob, C. Taïeb, Charbel Skayem, Abraham Getachew Kelbore, L. Misery, Therdpong Tempark, Alexander J. Stratigos, Martin Steinhoff, Jonathan I. Silverberg · 发表于：Journal of the European Academy of Dermatology and Venereology · 年份：2025 · DOI：10.1111/jdv.70138 · 被引用次数：2 · 研究领域：Dermatology and Skin Diseases、Asthma and respiratory diseases、Mental Health Treatment and Access

Due to its substantial psychosocial burden, atopic dermatitis (AD) is linked to an increased risk of suicidal ideation (SI).1-3 As part of the ‘Scars of Life’ study,4 we conducted a case–control analysis to assess the prevalence and risk factors of SI in a sample of adults representative of the general population with physician-confirmed AD, compared to adults without AD from the same population, across 27 countries. The survey collected sociodemographic variables, a subjective evaluation of SI (‘have you had suicidal ideation: in the last 24 months? before the age of 18’), itch and skin pain intensity (Visual Analog Scale, VAS), clinical severity [CSv] (POEM5) and skin-related stigmatization (PUSH-D6). Participants were contacted by email to complete a structured digital questionnaire. Among 15,223 individuals with current AD (8726 women, 6497 men), mean age was 41.1 years (SD 14.1). Of these, 7383 (48.5%) had adult-onset AD, 4965 (32.6%) adolescent-onset (10–18 years) and 2875 (18.9%) childhood-onset (<10 years). A control group [CG] composed of 4063 women and 3905 men, with a mean [SD] age of 43.7 [15.6] years, did not report AD. In the past 24 months, 2009 (13.2%) AD patients reported SI, compared to 678 (8.5%) in the CG (p < 0.01). The relative risk of SI in AD patients was thus 1.55 [95%CI: 1.42–1.69]-p < 0.001. In the adult-onset group, 12.7% reported SI during adolescence; however, in the group with childhood-onset and adolescence-onset, suicidal ideation was reported...