Pathway economy in cyclization of 1 ,n -enynes

作者：Hezhen Han, Wenjie Mao, Bin Lin, Maosheng Cheng, Lu Yang, Yongxiang Liu · 发表于：Beilstein Journal of Organic Chemistry · 年份：2025 · DOI：10.3762/bjoc.21.173 · 被引用次数：2 · 研究领域：Catalytic Alkyne Reactions、Cyclopropane Reaction Mechanisms、Synthetic Organic Chemistry Methods

-enyne cyclization, enabling divergent construction of complex molecular architectures from a single substrate class. Through mechanistic-guided modulation of catalysts, solvents, ligands, and angle strain, this approach achieves unprecedented reaction pathway control while demonstrating superior temporal and step efficiency compared to conventional methods. The work establishes a sustainable framework for rapid molecular diversification, offering transformative potential for green chemistry and pharmaceutical applications. By unifying mechanistic insights with practical synthetic design, this review provides valuable guidance for future innovations in precision organic synthesis.