White Matter Integrity of the Corpus Callosum Mediates the Association Between Aging and Skin Condition

作者：Daihaoyi Yuan, Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa · 发表于：Life · 年份：2025 · DOI：10.3390/life15111664 · 被引用次数：1 · 研究领域：RNA regulation and disease

This study examines whether white matter integrity mediates the link between psychological stress and skin aging. This cross-sectional study included 92 healthy Japanese adults (aged 22-62 years) who underwent diffusion tensor imaging to obtain Fractional Anisotropy Brain Healthcare Quotients (FA-BHQs) for major white matter tracts, while skin aging was assessed using Motion Scan Technology. Correlation analyses revealed significant associations among stress, skin aging, and FA-BHQ in the corpus callosum (CC) and internal capsule (IC). Mediation analyses suggested, at the statistical level, a potential that the CC fully mediates the association between stress and skin aging. These findings suggest a relationship between interhemispheric white matter integrity, psychological stress, and skin aging in line with the concept of the brain-skin axis.