The Eastern Cooperative Oncology Group Score Rather Than Donor Type Impacts Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia Patients Aged 51–60 Years: A Retrospective Study From the Chinese Blood and Marrow Transplant Registry

作者：Xin Zhao, Ming Zhou, Bao‐Dong Ye, Erlie Jiang, Dai‐Hong Liu, Peihua Lu, Fang Zhou, Guifang Ouyang, Ya‐Jing Xu, Xin Li, Weiwei Qin, Hai Yi, Guan‐Chen Bai, Zi‐Min Sun, Xuejun Zhang, Xuehong Ran, Jianping Zhang, Guohong Su, Jinxiong Huang, Tai‐Wu Xiao, Xianmin Song, Hui‐Xia Liu, Jinsong Yan, Kehong Bi, Xi Zhang, Xiao‐Jun Huang, Shun‐Qing Wang, Lan‐Ping Xu · 发表于：Clinical Transplantation · 年份：2025 · DOI：10.1111/ctr.70359 · 被引用次数：1 · 研究领域：Hematopoietic Stem Cell Transplantation、Acute Myeloid Leukemia Research、Renal Transplantation Outcomes and Treatments

Our study includes 103 patients aged between 51 and 60 years who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donors (MSDs) (n = 36), haploidentical donors (HIDs) (n = 56), and unrelated donors (URDs) (n = 11). Multivariate analysis exploring the relationship between risk factors and survival confirmed that survival outcomes were only independently impacted by Eastern Cooperative Oncology Group (ECOG) score (ECOG scores ≥2 vs. ECOG scores of 0-1, overall survival [OS] HR: 2.91 [95% CI 1.35-6.27], p = 0.006; failure free survival [FFS] HR: 2.93 [95% CI 1.33-5.88], p = 0.006; graft-versus-host disease-free/relapse-free survival [GRFS] HR: 2.80 [95% CI 1.33-5.88], p = 0.006), while age, specific donor source and hematopoietic cell transplantation-comorbidity index (HCT-CI) score did not significantly influence prognosis in this age group. After applying propensity score-matching (PSM) to balance the pretransplant clinical factors between patients with ECOG scores 0-1 cohort and those with ECOG scores ≥2 cohort, poor performance status remains a negative factor for survival outcomes (OS p = 0.04; FFS p = 0.03; GRFS p = 0.03). Further analysis in subgroup patients with HCT-CI scores 0-1 found the retained significance of ECOG score in predicting inferior survival. In conclusion, our results indicate good long-term results of allo-HSCT in elderly SAA adults regardless of donor type. Higher ECOG score is associated with poor post-tran...