Impact of Pullback Pressure Gradient on Clinical Outcomes after Percutaneous Coronary Interventions

作者：Kazumasa Ikeda, Takuya Mizukami, Koshiro Sakai, Frédéric Bouisset, Jeroen Sonck, Adriaan Wilgenhof, Hitoshi Matsuo, Toshiro Shinke, Hirohiko Ando, Masahiro Hada, Brian Ko, Simone Biscaglia, Fernando Rivero, Thomas Engstrøm, Antonio Maria Leone, Lokien X. van Nunen, William F. Fearon, Evald Høj Christiansen, Stephane Fournier, Liyew Desta, A. Yong, Julien Adjedj, Javier Escaned, Masafumi Nakayama, Ashkan Eftekhari, Danielle Keulards, Frederik M. Zimmermann, Tatyana Storozhenko, Bruno R. da Costa, Gianluca Campo, Colin Berry, Damien Collison, Tom Johnson, Daniel Munhoz, Tetsuya Amano, Divaka Perera, Allen Jeremias, Ziad A. Ali, Takashi Kubo, Kazuhiro Satomi, Nobuhiro Tanaka, Bernard De Bruyne, Nils P. Johnson, Carlos Collet · 发表于：Circulation Cardiovascular Interventions · 年份：2025 · DOI：10.1161/circinterventions.125.016022 · 被引用次数：6 · 研究领域：Coronary Interventions and Diagnostics、Cardiac Imaging and Diagnostics、Mechanical Circulatory Support Devices

BACKGROUND: Impaired flow following percutaneous coronary intervention (PCI) is a known predictor of adverse outcomes. The pullback pressure gradient (PPG) is a novel physiological metric that differentiates focal from diffuse disease and enables prediction of post-PCI fractional flow reserve (FFR). This post hoc analysis of the PPG Global (NCT04789317) study aimed to evaluate the prognostic performance of a PPG model for predicting post-PCI FFR and to determine whether the predicted physiological outcome is associated with adverse events following PCI. METHODS: Prospective and multicenter study including patients with hemodynamically significant coronary artery disease undergoing PCI. A prediction model based on FFR and PPG was used to estimate post-PCI FFR. Based on the predicted values, vessels were classified as having either optimal or suboptimal post-PCI physiology. The primary end point was target vessel failure at 1 year. Target vessel failure was defined as a composite of cardiac death, target-vessel myocardial infarction, and ischemia-driven target vessel revascularization. RESULTS: A total of 855 patients (890 vessels) were analyzed. The mean difference between predicted and measured post-PCI FFR was 0.001 (limits of agreement, –0.10 to 0.10). There was a strong correlation between predicted and measured delta FFR ( r =0.92 [95% CI, 0.91–0.93]; P <0.001). Vessels with predicted suboptimal post-PCI physiology had a significantly higher incidence of target vessel ...