Harnessing hollow Prussian blue nanozymes for efficient photothermal lithotripsy while protecting the kidneys from oxidative stress injury

作者：Ziyu Ye, Yuan Tian, Hantian Guan, Yue Zhuo, S M Wang, Xiangya Luo, Hongxing Liu, Wen Zhong · 发表于：Materials Today Bio · 年份：2025 · DOI：10.1016/j.mtbio.2025.102467 · 被引用次数：5 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Nanocluster Synthesis and Applications

Kidney stones, given the high incidence and recurrence rates, pose a critical challenge to public health. High-power laser lithotripsy may potentially induce damage to renal tissues, while existing therapeutic drugs have limitations in relieving the damage to renal tubular epithelial cells induced by oxidative stress. This injury promotes crystal aggregation and adhesion, further exacerbates cell damage and forming a vicious cycle. To address this problem, we proposed hollow Prussian blue (HPB) nanozymes for efficient photothermal lithotripsy while protecting the kidneys from oxidative stress injury. The in vitro lithotripsy results demonstrate that the efficiency of lithotripsy could be enhanced by adhering HPB to the surface of kidney stones thanks to its photothermal effect and stability characteristic under low power 808nm near-infrared laser. No significant renal tissue damage was observed after the procedure, indicating its safety. In vitro HPB can simulate the activities of various antioxidant enzymes, thereby scavenge free radicals and protect cells from oxidative stress damage. Meanwhile, an animal model of renal CaOx crystals induced by glyoxylate was established to explore the safety and therapeutic effect of HPB. HPB could scavenge reactive oxygen species (ROS) and attenuate oxidative stress through its excellent biocompatibility and antioxidant enzyme activity, which protects renal tubular cells, upregulates the expression of antioxidant enzymes, downregulates pr...