Clinical characteristics and mortality risk factors of Streptococcus constellatus infection: A retrospective cohort study of 390 patients

作者：Jie Sun, Tong Xiang, Sitong Liu, Shijie Zhang, Lian Wang, Dongguang Wang, Qingqing Jia, Xing He, Weiming Lv, MAA Qasem, Yuling Xiao, Hong Fan · 发表于：Journal of Infection and Public Health · 年份：2025 · DOI：10.1016/j.jiph.2025.103023 · 被引用次数：2 · 研究领域：Streptococcal Infections and Treatments、Infective Endocarditis Diagnosis and Management、Neonatal and Maternal Infections

BACKGROUND: Few studies have investigated the clinical characteristics and mortality associated with Streptococcus constellatus (S.constellatus) infection. To identify the clinical features and mortality of patients with S. constellatus infection. METHODS: This retrospective cohort study analyzed hospitalized patients with confirmed S.constellatus infection at West China Hospital of Sichuan University from January 2016 to April 2024. S. constellatus was identified using sterile body fluid culture or metagenomic next-generation sequencing (mNGS). Patients were categorized as monomicrobial or polymicrobial infection. Kaplan-Meier curve analysis was performed to compare the 30-day survival rates based on infection type and infection site, while multivariate Cox regression was conducted to identify independent risk factors for 30-day mortality. RESULTS: Of the 390 patients, 301 (77.2 %) were classified as monomicrobial S. constellatus infection. S. constellatus isolates were highly susceptible to penicillin (98.08 %) and levofloxacin (98.90 %).Overall 30- and 90-day mortality were 13.08 % and 15.13 %, higher in polymicrobial than monomicrobial infections (24.72 % vs 8.97 % at 30 days; 29.21 % vs 10.96 % at 90 days). Polymicrobial infection (adjusted hazard ratio [aHR] = 2.426, p = 0.007) and brain abscess (aHR = 16.689, p < 0.001) were identified as independent risk factors for 30-day mortality in patients with S. constellatus infection. In the subgroup of monomicrobial infection...