Prevalence and correlates of breathlessness in adults: an umbrella review and updated systematic review with meta-analysis in general and clinical populations

作者：Cheng Cheng, Naomi Takemura, Helen K. Reddel, Charles C. Reilly, David C. Currow, Ka Yan Ho, Fanny W.S. Ko, Jane Phillips, Janelle Yorke · 发表于：European Respiratory Review · 年份：2025 · DOI：10.1183/16000617.0104-2025 · 被引用次数：6 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Respiratory and Cough-Related Research、Obstructive Sleep Apnea Research

BACKGROUND: Breathlessness is a debilitating symptom affecting many adults, yet its prevalence and correlates are not well summarised. This review synthesised evidence on breathlessness prevalence, correlates and assessment methods across general and clinical populations. METHODS: We undertook an umbrella review and updated systematic review using a comprehensive search of three databases up to January 2025. The umbrella review incorporated existing systematic reviews and meta-analyses, while the updated systematic review and meta-analysis included original studies published after the most recent eligible review. RESULTS: The umbrella review encompassed 10 reviews conducted between 2010 and 2025, incorporating 315 studies. The primary tool for assessing self-reported breathlessness was the Medical Research Council questionnaire and its modified version (mMRC). The prevalence of breathlessness ranged from 0.9% to 61.6% in general populations and from 20.4% to 87% in clinical populations. Six categories of breathlessness correlates were identified: sociodemographic, physiological, clinical, psychological, environmental and radiological/pathological factors. An updated systematic review and meta-analysis found 15 studies published between 2021 and 2024 reporting prevalence of breathlessness. Using the most common criterion of an mMRC score ≥2, the pooled prevalence was 12.5% (range 3.7-29.5%) in general populations and 37.5% (range 27.5-48.6%) in clinical populations. These stud...