Joint association of triglyceride-glucose index and obesity indicators with stroke risk: a nationwide prospective cohort study

作者：Zhihui Li, Yue Ban, Minli Hu, Liping Deng, Xiaohua Xie · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-21331-9 · 被引用次数：10 · 研究领域：Acute Ischemic Stroke Management、Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Health and Disease Prevention

The triglyceride-glucose (TyG) index has been identified as an independent predictor of stroke risk. However, the comprehensive impact of combined indices, integrating TyG with obesity indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), on stroke risk remains insufficiently explored. Furthermore, there is a paucity of research on combined indices involving TyG and other obesity indicators like the weight-adjusted waist index (WWI), body roundness index (BRI), and a body shape index (ABSI). This study aimed to comprehensively evaluate the combined impact of TyG with various obesity indicators on stroke risk and to investigate their potential associations. This observational cohort study included 8,730 participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox proportional hazards models, smooth curve fitting, and threshold effect analysis were employed to explore the potential relationships between the combined indices and stroke risk. The predictive value of TyG alone, obesity indicators, and the combined indices for stroke risk was compared using the area under the receiver operating characteristic (ROC) curve (AUC), and was validated by Delong test. Kaplan-Meier curves were used to illustrate the cumulative incidence of stroke events. Over a median follow-up of 7 years, 456 (5.20%) incident stroke cases were identified. After adjusting for confounding factors, non-linear relationships were observed be...