Fe and Ni Dual-Atom Catalysts as High-Efficiency Coreaction Accelerators to Enhance the Electrochemiluminescence of the Carbon Dots/S 2 O 8 2– System for Assessing the Acute Myocardial Infarction Protein Marker

作者：Jiayi Jin, Xiaochun Zhu, Pan Zhou, Haijiao Xie, Xin Peng, Yaqin Chai, Ruo Yuan · 发表于：Analytical Chemistry · 年份：2025 · DOI：10.1021/acs.analchem.5c04625 · 被引用次数：2 · 研究领域：Advanced biosensing and bioanalysis techniques、Advanced Nanomaterials in Catalysis、Biosensors and Analytical Detection

Herein, Fe and Ni dual-atom catalysts (DACs) (FeNi DACs)-doped carbon dots (CDs) (FeNi DACs-CDs) as novel electrochemiluminescence (ECL) emitters with outstanding ECL performance were developed for assessing the protein biomarker insulin-like growth factor-1 (IGF-1) of acute myocardial infarction (AMI). Specifically, the FeNi DACs in the CDs as high-efficiency coreaction accelerators promoted the production of abundant reactive SO 4 •– from the coreactant S 2 O 8 2– for substantially enhancing the ECL performance of the FeNi DACs-CDs/S 2 O 8 2– system. More importantly, compared to single-atom catalysts with only single-atom active sites, the FeNi DACs possessing dual-atom active sites synergistically enriched S 2 O 8 2– on the surfaces of the FeNi DACs-CDs and catalyzed the reduction of S 2 O 8 2– for generating more reactive radicals under electrical excitation, as verified by the lower adsorption energy of S 2 O 8 2– on the FeNi DACs-CDs and the intensified signals in the in situ electron paramagnetic resonance spectrum of the FeNi DACs-CDs/S 2 O 8 2– system, resulting in excellent cathodic ECL emission of the FeNi DACs-CDs. Furthermore, the immunoassay platform designed based on highly efficient FeNi DACs-CDs emitters sensitively detected IGF-1 with a low detection limit (limit of detection) of 0.56 fg·mL –1, enabling the assessment of IGF-1 levels in human serum samples. This work proposes an emerging strategy for designing high-performance ECL emitters, indicating their...