Copper Single-Atom Catalysts Boosting Electrochemiluminescence of Iridium Nanoparticles for Perfluorooctanoic Acid Analysis

作者：Guomin Yang, Jinwen Zhao, Rongfang Li, Ruo Yuan, Fangxin Hu, Shihong Chen · 发表于：Nano Letters · 年份：2025 · DOI：10.1021/acs.nanolett.5c04438 · 被引用次数：3 · 研究领域：Advanced biosensing and bioanalysis techniques、CO2 Reduction Techniques and Catalysts、Nanocluster Synthesis and Applications

Iridium complexes have always been the predominant focus in traditional iridium-based electrochemiluminescence (ECL) luminophores. However, their application often involves a laborious preparation process and significant costs. This study innovatively developed a simple and cost-effective method that enabled the direct synthesis of iridium nanoparticles (Ir NPs) from iridium trichloride. This synthesis was achieved through the reduction of iridium ions by 6-aza-2-thiouridine and the inhibition of nonradiative decay of Ir NPs by l -arginine as a second ligand. Moreover, copper single atoms anchored on defect-engineered UiO-66 were developed to significantly enhance ECL emission of Ir NPs at −2.0 V through efficiently catalyzing the generation of sulfate radical species from the coreactant S 2 O 8 2 – . Ir NPs@Cu sa /UiO-66 was integrated with an aptamer recognition-driven nucleic acid amplification strategy to enable ultrasensitive ECL detection of perfluorooctanoic acid.