Research progress on cellular behavior of CaSR in cardiovascular diseases

作者：xinyu liu, Tao Xie, Javeria Qadir, Shuang Li, Tianshuang Xu, Lu Yang, Xiaotian Ge, Hui Yuan · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1672536 · 被引用次数：1 · 研究领域：Endoplasmic Reticulum Stress and Disease、Mitochondrial Function and Pathology、S100 Proteins and Annexins

IntroductionCardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, posing a major burden on global health system.Despite advancements in diagnosis and therapy, the underlying cellular and molecular mechanisms contributing to the development and progression of CVDs are not fully understood (1).Among them, the dysregulation of calcium signal transduction, as a crucial pathological physiological process, is receiving increasing attention, particularly in terms of calcium signal imbalance and its impact on the survival and function of cardiac cells.Therefore, Calcium-sensing receptor (CaSR) can serve as an important target for the treatment of cardiovascular diseases.CaSR is a cell surface receptor that functions by sensing the concentration of Ca 2+ in the extracellular matrix (ECM), thus, serving as a primary regulator of calcium homeostasis.Calcium is an important ion in the cells, highly ubiquitous and an integral intracellular messenger that participates in various biological processes (2-4).The alterations in extracellular Ca 2+ concentration can affect normal cellular activities and physiological functions of these systems.Several cardiovascular conditions, including hypertension, atherosclerosis, cardiac hypertrophy, myocardial infarction (MI), and vascular calcification, have been associated with altered CaSR expression or signaling.These associations have spurred growing interest in the therapeutic modulation of CaSR using pharmaco...