Regioisomeric Control of Triexplosophoric Groups on a 1,2,4-Triazole Scaffold for an Enhanced Energy-Stability Balance

作者：Ning Ding, Pengcheng Guo, Yanda Jiang, Xudong Xu, Qi Sun, Shenghua Li, Siping Pang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c03830 · 被引用次数：6 · 研究领域：Energetic Materials and Combustion、Combustion and Detonation Processes

Regioisomeric control is presented as a precise strategy to resolve the energy-stability conflict in trifunctionalized 1,2,4-triazole energetic materials. By positioning a stabilizing amino group adjacent to a highly energetic trinitromethyl group, a new molecule, 1-trinitromethyl-3-nitro-5-amino-1,2,4-triazole (TN-ANTA), was designed and synthesized. Compared to its reported isomer, TN-ANTA exhibits a superior combination of high density (1.905 g/cm 3 vs 1.878 g/cm 3 ), enhanced thermal stability (T dec = 128 °C vs 119 °C), and markedly improved impact sensitivity (7 J vs 1 J). Mechanistic studies reveal that this enhancement stems from a combination of more compact crystal packing, driven by stronger intermolecular interactions, and a higher bond dissociation energy of the weakest C-NO 2 bond due to intramolecular stabilization. The superiority of this design principle was further validated as the energetic salts of TN-ANTA also consistently displayed higher densities and thermal stabilities than their corresponding isomers. This work establishes regioisomeric placement of functional groups as a powerful approach for the rational design of advanced energetic materials.