#465 Relationship between tissue hydration and peritoneal membrane transport

作者：Fansan Zhu, Nadja Grobe, Xiaoling Wang, Hasib Absar, Xin Wang, Lela Tisdale, Laura Merlo, Maricar Villamar, Jun Yi, Manuela Stauss‐Grabo, Len A. Usvyat, Peter Kotanko · 发表于：Nephrology Dialysis Transplantation · 年份：2025 · DOI：10.1093/ndt/gfaf116.0693 · 研究领域：Dialysis and Renal Disease Management

Abstract Background and Aims The peritoneal equilibration test (PET) is essential for understanding peritoneal membrane transport in peritoneal dialysis (PD) treatment. However, peritoneal membrane function can be influenced by numerous factors, including fluid status. The aim of this study was to investigate whether tissue hydration influences PET results, including D/P creatinine and D/D0 glucose. Method Standard PET was performed with 2.5% glucose and 2 L of dialysate for a 4-hour dwell. Whole body and calf bioimpedance (Hydra 4200, Xitron Technologies, San Diego, CA) were measured in a sitting position, both pre- and post-PD treatment. Whole body extracellular volume (wECV) was estimated using the Xitron program. Calf normalized resistivity (CNR = resistance *cross-sectional area / body mass index) was defined (Fig. 1) as a hydration marker to evaluate fluid status in dialysis patients in our previous study (Zhu et al. Physiol Meas, 32:887–902, 2011). The concentrations of creatinine and glucose in blood plasma (P) and dialysate (D) samples were measured using standard methods. P/D creatinine and D/D0 glucose ratios were calculated to assess the function of peritoneal membrane transport. Linear regression analysis was used to determine the relationship between CNR and transport parameters. One-way ANOVA was used to identify differences in the changes of wECV (∆wECV) and CNR (∆CNR) during PD among different transport groups of patients. Results Sixteen PD patients (age 56....