Global, regional, and national burden of 34 cancer groups across 204 countries and territories, 1990–2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021

作者：Linfeng Zhu, Jiangpeng Zhu, Qingsong Wang, Xiaotong Sun, YuTao Yuan, Sheng Ding, Jiafeng Zhao, Lei Liu, Shuangshuang Hou · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1660125 · 被引用次数：9 · 研究领域：Global Cancer Incidence and Screening、Economic and Financial Impacts of Cancer、Multiple and Secondary Primary Cancers

Introduction: Detailed, comprehensive, and timely reporting on cancer incidence, mortality, and associated burdens is essential for understanding the evolving trends of this complex disease. This study aims to evaluate the burdens of 34 types of cancer across 204 countries and territories from 1990 to 2021, incorporating the latest epidemiological data to provide a framework for policy discussions, resource allocation, and research prioritization. Methods: Using data from the Global Burden of Disease (GBD) 2021 study, we analyzed 34 cancer types across 204 countries from 1990 to 2021, stratifying by age, sex, region, and sociodemographic index (SDI) and projecting future trends using a Bayesian age-period-cohort model. Results: In 2021, there were 23.57 million new cases and 9.83 million deaths, with a global age-standardized incidence rate (ASIR) of 275.2 per 100,000 and age-standardized mortality rate (ASMR) of 115.8 per 100,000. Cancer incidence has risen 2.3-fold, with the ASIR increasing by 8.8% and the ASMR decreasing by 21.5% over the period since 1990. Tracheal, bronchial, and lung cancer, colorectal cancer, stomach cancer, and breast cancer were the leading causes of mortality, while nonmelanoma skin cancer, tracheal, bronchial, and lung cancer, colorectal cancer, breast cancer, and prostate cancer had the highest incidence rates. Men had 1.2 times higher incidence and 1.3 times higher mortality than women. North America had the highest ASIR, while East Africa had th...